Hollow mno2 as a tumor-microenvironment

Author: mwhj

August undefined, 2024

Nettet13. mai 2024 · Hollow mesoporous copper sulfide nanoparticles (HMCuS NPs) are advantageous for loading small-molecule therapeutic drugs coupled with photothermal ablation for synergistic tumor therapy. However, treatment efficacy mediated by HMCuS NPs is not always satisfactory owing to their insensitivity toward the tumor … NettetOnce exposed to a tumor microenvironment, ... Cui Y, Yan X, et al. Controlled preparation of MnO2 hierarchical hollow nanostructures and their application in water treatment. Adv ... Zhao Z, Fan H, Zhou G, et al. Activatable fluorescence/MRI bimodal platform for tumor cell imaging via MnO2 nanosheet-aptamer nanoprobe. J Am Chem …

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Nettet10. apr. 2024 · Furthermore, with the help of Col and H-MnO2, MP@H-MnO2-Dox-Col could alleviate tumor hypoxia and improve the penetration, ... Chao Y, Xu J, Sun X, Wu Y, Peng R, Liu Z. Hollow MnO 2 as a tumor-microenvironment-responsive biodegradable nano-platform for combination therapy favoring antitumor immune responses. Nat … Nettet27. feb. 2024 · An activatable theranostic platform based on multifunctional MnO 2 -coated mesoporous silica nanoparticles (MS@MnO 2 NPs) has been developed for MRI-monitored combination chemotherapy and chemodynamic therapy (CDT). ADS=antioxidant defense system. Abstract peter posthumus

Tumor microenvironment-responsive multifunctional nanoplatform based …

Nettet1. des. 2024 · Herein, a novel hollow mesoporous double-shell Co 9 S 8 @MnO 2 nanoplatform loaded with photodynamic agent of indocyanine green molecules (ICG) … NettetAfter being internalized into the tumor tissue, the nanomedicine (MnCO@hMSN) will react with H 2 O 2 in the tumor (a new Fenton-like reaction that releases CO gas in situ) to achieve antitumor effects. In vivo experiments have shown that within the treatment cycle. starr international insurance

Hollow MnO2 as a tumor-microenvironment-responsive ... - Nature

Overcoming chemotherapy resistance using pH-sensitive …

NettetThe morphology control of the MnO 2 hollow spheres can be easily achieved by altering the mass ratio of Pluronic F-127 to silica spheres. Material characterizations reveal that urchin-like hollow spheres possess the highest BET surface area of 233.4 m 2 g −1 among the diverse morphologies. Nettet15. feb. 2024 · In this study, platelet membrane (PLTM) biomimetic hollow MnO 2 nanoparticles were prepared and these were investigated for delivery of bufalin. Additionally, these nanoparticles, in response to the tumor microenvironment, showed rapid drug release and generated the hydroxyl radicals (HO) by the Fenton reaction … peter postl bathNettetHerein, an intelligent biodegradable hollow manganese dioxide (H-MnO2) nano-platform is developed for not only tumor microenvironment (TME)-specific imaging … peter potamus caboose caboose tvark

"NettetHerein, an intelligent biodegradable hollow manganese dioxide (H-MnO 2 ) nano-platform is developed for not only tumor microenvironment (TME)-specific imaging and on-demand drug release, but also modulation of hypoxic TME to enhance cancer therapy, resulting in comprehensive effects favoring anti-tumor immune responses. With hollow … " - Hollow mno2 as a tumor-microenvironment

Hollow mno2 as a tumor-microenvironment

NettetUniform MnO2 hollow nanospheres with hierarchical (urchin-like and flower-like) and non-hierarchical structures have been synthesized via a dual-template assisted … Nettet12. okt. 2024 · Herein, an intelligent biodegradable hollow manganese dioxide (H-MnO 2) nano-platform is developed for not only tumor microenvironment (TME)-specific imaging and on-demand drug release, but also modulation of hypoxic TME to enhance cancer therapy, resulting in comprehensive effects favoring anti-tumor immune responses.

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NettetIn this study, we synthesised hollow manganese dioxide nanoparticles (HMDNs) loaded with the hydrophilic chemotherapeutic drug (acriflavine, ACF) and the hydrophobic … NettetRecently, it has been reported MnO 2 shell was decomposed in tumor microenvironment to release Mn 2+, which can catalyze H 2 O 2 to produce •OH at the presence of HCO 3- in physiological environments by a Fenton-like reaction manner as that catalyzed by iron ions 36. This process consumes glutathione (GSH) and enhances CDT effect simultaneously.

Nettet10. apr. 2024 · Results shows that MP@H-MnO2-Dox-Col can increase the Dox effect with low cardiotoxicity based on multi-functions of effective penetration in tumor tissue, alleviating hypoxia in TME, pH sensitive drug release as well as targeted delivery of Dox. Doxorubicin (Dox) has been recommended in clinical guidelines for the standard-of … NettetThis study developed a novel multifunctional nano-snowflake probe (USPIO@MnO2@Ce6, UMC) for oxygen-enhanced photodynamic therapy.

NettetMnO 2 catalyzes the intracellular hydrogen peroxide (H 2 O 2 ) to produce oxygen (O 2 ), reversing the hypoxic TME in vivo. The generated O 2 is converted into singlet oxygen ( 1 O 2 ) by the TPyP shell under near-infrared light, which can inhibit tumor proliferation. NettetRegulating the tumor microenvironment (TME) has been a promising strategy to improve antitumor therapy. Here, a red blood cell membrane (mRBC)-camouflaged hollow MnO 2 (HMnO 2) catalytic nanosystem embedded with lactate oxidase (LOX) and a glycolysis inhibitor (denoted as PMLR) is constructed for intra/extracellular lactic acid exhaustion …

Nettet7. aug. 2024 · Significantly, the multiple-tumor-microenvironment-responsive features of MnO also provides intelligent MRI and thermal imaging guidance for synergistically enhancing PDT, PTT, and chemotherapy, thus offering an intelligent versatile toolbox for multifunctional nanotheranostic applications. Graphical Abstract Material Advancement …

Nettet12. okt. 2024 · Abstract. Herein, an intelligent biodegradable hollow manganese dioxide (H-MnO 2) nano-platform is developed for not only tumor microenvironment (TME) … peter postlethwaite moviesNettet10. apr. 2024 · Download Citation Biomimetic liposomal nanozymes improve breast cancer chemotherapy with enhanced penetration and alleviated hypoxia Background Doxorubicin (Dox) has been recommended in ... peter potamus and his magic flying balloonNettet26. mai 2024 · Here, intelligent “theranostic” platforms were synthesized based on hollow mesoporous MnO2 (H-MnO2) nanoshells that were loaded with chemotherapy agents … peter posh wolverhamptonNettetThe hollow mesoporous MnO2(H-MnO2) nanoshells were obtained after incubating MnO2@SiO2nanoparticles with a Na2CO3solution to dissolve silica. To enhance their … peter possert oncologyNettet24. apr. 2024 · Tumor microenvironment responsive Ce6-MnO2/CNTs nanoplatform, with oxygen-self-generation property and enhanced permeability and retention effect, has been successfully prepared for synergistic photo... peter posh telford shropshireNettet12. okt. 2024 · The hollow mesoporous MnO 2 (H-MnO 2) nanoshells were obtained after incubating MnO 2 @SiO 2 nanoparticles with a Na 2 CO 3 solution to dissolve silica. To enhance their water solubility and... starrisus shopNettetHerein, an intelligent biodegradable hollow manganese dioxide (H-MnO 2) nano-platform is developed for not only tumor microenvironment (TME)-specific imaging and on … peter potamus did you get that thing gif