Lamp2b血清组学

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August undefined, 2024

Tīmeklis2024. gada 21. marts · LAMP2 (Lysosomal Associated Membrane Protein 2) is a Protein Coding gene. Diseases associated with LAMP2 include Danon Disease and Left … TīmeklisRP-A501 is an investigational gene therapy product being developed for Danon Disease and the first potential gene therapy for monogenic heart failure. It consists of a recombinant adeno-associated serotype 9 (AAV9) capsid containing a functional version of the human LAMP2B transgene (AAV9. LAMP2B ).

工程化外泌体——药物递送专家&外泌体研究利器 - 知乎

Tīmeklis2024. gada 31. maijs · (i) First, we constructed an EGFP-C1-iRGD-Tyr7-Lamp2b lentiviral vector containing exosomal membrane protein (Lamp2b) genes, tyrosine genes, and iRGD peptide genes for transfection into HEK-293T cells to obtain a new type of exosome (iRGD-Exos). The surface of these exosomes was enriched with … TīmeklisThe LAMP2 mRNA undergoes alternative splicing resulting in the generation of three isoforms: LAMP2a, LAMP2b, and LAMP2c, which have similar luminal regions but … bling christmas pillows

LAMP2B抗体 Abcam中文官网

Tīmeklis利用携带软骨细胞的亲合肽（CAP）融合表达展示于外泌体膜蛋白（lamp2b）上表面作为靶向的基因工程化外泌体可实现靶向软骨细胞（图1）。与无靶向的天然外泌体相 … Tīmeklis2024. gada 23. maijs · The expression of CTP-Lamp2b peptide on exosomes was stabilized by attaching glycosylation sequences. Exosomes expressing only Lamp2b … Tīmeklis2024. gada 15. dec. · Abstract. Huntington’s disease is an autosomal-dominant neurodegenerative disease caused by CAG expansion in exon 1 of the huntingtin (HTT) gene.Since mutant huntingtin (mHTT) protein is the root cause of Huntington’s disease, oligonucleotide-based therapeutic approaches using small interfering RNAs … fred korematsu achievments

RVG-modified exosomes derived from mesenchymal stem cells …

LAMP2B抗体- Lysosome Marker Abcam中文官网

Tīmeklis2024. gada 28. marts · 研究人员确定以下几种蛋白是该机制的基本组成部分：溶酶体相关膜蛋白2的同工型A (LAMP2A)，此前被认为是一种将含有KFERQ的底物靶向溶酶体的蛋白质；以及分子伴侣热休克蛋白HSC70。此外，研究人员证明蛋白质的包装发生在早期的内体膜上，并且依赖于内体蛋白CD63、Alix、Syntenin-1和RAB31，而不依赖 … Tīmeklis2024. gada 1. dec. · A fusion protein of RVG and Lamp2b was expressed in 293T cells. Since Lamp2b is an exosome membrane-integral protein, RVG-Lamp2b is integrated into the exosomes, producing RVG-decorated exosomes (RVG-Exo). HMGB1-siRNA was loaded into RVG-Exo and unmodified exosomes (Unmod-Exo) by electroporation. bling christmas ornamentsTīmeklis2024. gada 24. dec. · Here, we demonstrate that LAMP-2B promotes autophagosome–lysosome fusion in cardiomyocytes (CMs), independently of STX17. … fred korematsu background information

"Tīmeklis2024. gada 2. jūn. · 令人兴奋的是，一项突破性的研究证明了狂犬病毒糖蛋白（RVG）可以通过融合蛋白溶酶体相关膜糖蛋白2b（Lamp2b）-RVG进行工程化，定位在EV的表面，从而有可能实现针对大脑的靶向。该报道设想了通过构建携带circRNA的工程EV在体内将候选circRNA传递到大脑的潜力。该研究在缺血性脑损伤中探索了这种circRNA递 … " - Lamp2b血清组学

Lamp2b血清组学

Tīmeklis2024. gada 25. marts · LAMP2A is required for the sorting of selected proteins into extracellular vesicles To investigate the impact of LAMP2A in exosome protein cargo, we used the CRISPR-Cas9 system to knock out (KO) the LAMP2A gene in a human cell line with normal chromosome number, ARPE-19. Tīmeklis2024. gada 1. febr. · The pEGFP-C1-RVG-Lamp2b expressing vector was kindly provided by Prof. Matthew J A Wood’ lab from University of Oxford [70]. DNA sequence encoding the glycosylation sequon (GNSTM), E7 Peptide [55] and a glycine-serine spacer were synthesized and subcloned to replace the RVG fragment by XhoI/BspeI …

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TīmeklisLAMP2 has 3 distinct isoforms, LAMP2A, 2B & 2C which are expressed in different tissues and differ in sequence at the extreme C-terminus. Database link: P13473 … Tīmeklis使用人 LAMP2 蛋白氨基端特异的重组蛋白对动物进行免疫接种来产生单克隆抗体。背景溶酶体相关膜蛋白 1 和 2（LAMP1 和 LAMP2）是两种含量丰富的溶酶体膜蛋白 …

Tīmeklis2024. gada 27. sept. · LAMP-2 Antibody (H4B4) is an IgG 1 κ mouse monoclonal LAMP-2 antibody (also designated LAMP2 antibody, LAMPB antibody or lysosomal … Lysosome-associated membrane protein 2 (LAMP2), also known as CD107b (Cluster of Differentiation 107b) and Mac-3, is a human gene. Its protein, LAMP2, is one of the lysosome-associated membrane glycoproteins. The protein encoded by this gene is a member of a family of membrane glycoproteins. This … Skatīt vairāk The gene for LAMP2 has 9 coding exons and 2 alternate last exons, 9a and 9b. When the last exon is spliced with the alternative exon, it is a variant called LAMP2b, which varies in the last 11 amino acids of its C … Skatīt vairāk Lysosomes are cell organelles found in most animal cells. Their main functions center around breaking down materials and debris in the … Skatīt vairāk • CA77.1 • QX39 Skatīt vairāk • Chang MH, Karageorgos LE, Meikle PJ (2003). "CD107a (LAMP-1) and CD107b (LAMP-2)". Journal of Biological Regulators and Homeostatic Agents. 16 (2): 147–51. PMID 12144129. • Schleutker J, Haataja L, Renlund M, Puhakka L, Viitala J, Peltonen L, … Skatīt vairāk LAMP2 has been specifically implicated in tumor cell metastasis. Both LAMP1 and LAMP2 have been found expressed on the surface of cancerous tumors, specifically in cells of highly metastatic cancer such as colon cancer and melanoma. They are rarely found on … Skatīt vairāk • Cluster of differentiation Skatīt vairāk • LAMP2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • PDBe-KB provides an … Skatīt vairāk

TīmeklisPlasmid pCDNAHygro(+)LAMP2B from Dr. Janice Blum's lab contains the insert Lysosome-associated membrane protein 2b and is published in Immunity. 2005 May;22(5):571-81. This plasmid is available through Addgene. Image: Illustrated plasmid map in PNG format. GenBank File: Plasmid sequence and annotations. Use text … Tīmeklis2024. gada 25. marts · When comparing LAMP2A with LAMP2B endosomes, the distribution of the different components was asymmetric. Higher levels of TSG101 …

TīmeklisPlasmid pcDNA Flag Lamp2b-HA from Dr. Joshua Leonard's lab contains the insert Lamp2b and is published in J Biol Chem. 2015 Mar 27;290(13):8166-72. doi: 10.1074/jbc.M114.621383. Epub 2015 Feb 5. This plasmid is …

Tīmeklis一种基于Lamp2b的融合蛋白可用于在表面显示狂犬病病毒糖蛋白（RVG），当这些胞外体被系统地给予时，表面展示的RVG导致这些胞外体在小鼠的神经元和大脑中积聚 … bling christmas stockingsTīmeklis2024. gada 18. marts · LAMP2B is the predominant isoform expressed in cardiomyocytes. This study evaluates the efficacy of human LAMP2B gene transfer … fred korematsu cause of deathTīmeklis2024. gada 13. maijs · Background Exosomes are lipid-bilayer enclosed nano-sized vesicles that transfer functional cellular proteins, mRNA and miRNAs. Mesenchymal stem cells (MSCs) derived exosomes have been demonstrated to prevent memory deficits in the animal model of Alzheimer’s disease (AD). However, the intravenously … bling christmas shirts for womenTīmeklis定制系统分为蛋白质递送系统与RNA递送系统，蛋白质包装系统内含有3个质粒:第一个载有目的蛋白质包装装置(CD63+目的蛋白)；第二个载有特殊靶向运送功能的模块(例 … bling christmas nailsTīmeklis2024. gada 15. okt. · LYSOSOME-ASSOCIATED MEMBRANE PROTEIN B; LAMPB LYSOSOMAL MEMBRANE GLYCOPROTEIN, 110-KD; LGP110 CD107B HGNC Approved Gene Symbol: LAMP2 Cytogenetic location: Xq24 Genomic coordinates (GRCh38): X:120,426,148-120,469,349(from NCBI) Gene-Phenotype Relationships fred korematsu early lifeTīmeklisLAMP2 has three isoforms: LAMP2A, LAMP2B, and LAMP2C. LAMP2B is the predominant isoform expressed in cardiomyocytes. This study evaluates the efficacy … fred korematsu activismTīmeklisLAMP2A and LAMP2B are ubiquitously expressed, whereas LAMP2C is tissue specific. (C) Peripheral blood human B cells were treated for 24 h with R848, CpG, or left untreated (NS). Gene expression of ... bling christmas tops