List of lysosomotropic agents
WebDownload Table LogP and pKa values and molecular structures of the lysosomotropic drugs used in this work from publication: Lysosomal accumulation of anticancer drugs … WebThe compounds that accumulate in lysosomes are classified as lysosomotropic agents. Roshan Ashoor, Rolla Yafawi, Bart Jessen, Shuyan Lu, 'The Contribution of …
List of lysosomotropic agents
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WebIntroduction. As a recognized food-grade preservative, sodium benzoate (SB), whose structure is shown in Fig. 1, is widely used in the food, cosmetic, and pharmaceutical industries [1–3].For example, in the food industry, SB is used in a variety of foods and beverages, such as salads, kimchi, carbonated beverages, jams, juices, and soy sauce, … WebSome of these drugs -particularly azithromycin and other macrolides, indomethacin and some other non-steroidal anti-inflammatory drugs, proton pump inhibitors and …
Web30 okt. 2024 · The concept of lysosomotropic agents significantly changed numerous aspects of cellular biochemistry, biochemical pharmacology, and clinical medicine. In the … Web1 aug. 2024 · Some lysosomotropic compounds used in experimental work on endolysosomal trafficking and function include the tricyclic antidepressants, imipramine and amitriptyline; the antipsychotic, chlorpromazine; and the selective serotonin re-uptake inhibitor, fluoxetine [50].
Web1 aug. 2024 · Some lysosomotropic compounds used in experimental work on endolysosomal trafficking and function include the tricyclic antidepressants, imipramine … Web22 nov. 2013 · It is well documented that lysosomotropic agents can trigger lysosomal membrane permeabilization [52,53]. We have previously shown that the cell death associated with lysosomotropic compounds can be rescued by Bafilomycin A, which increases lysosomal pH and prevents compound accumulation, further supporting …
WebLysosomotropic agents include kinase inhibitors such as ML-9, 179 metal nanoparticles (NPs), 180 and some pharmaceutically important drugs, which include nortriptyline, siramesine, desipramine, clomipramine, imipramine, etc. 48 The chemical structure of some of these compounds is listed in Figure 4.
WebBackground: Lysosomotropic molecules are taken up into lysosomes in vitro and in vivo. Many drugs approved for clinical medicine are lysosomotropic agents, characterized by promoting particular effects including cytoplasmic vacuolization, increase in number and size of lysosomes, inhibition of their enzymes and accumulation of undegraded material, … imgur best part of being marriedWeb24 mrt. 2024 · agents with lysosomotropic properties might also demonstrate clinical effectiveness in the treatment of COVID-19. In this review, we discuss commonly used … list of post bacc programs for medical schoolWebLysosomal exocytosis is also perturbed in a variety of lysosomal and lipid storage disorders (reviewed in Samie and Xu, 2014;Settembre and Ballabio, 2014), and lysosomal exocytosis can drive the... imgur beta opt outWebRoles of lysosomotropic agents on LRRK2 activation and Rab10 phosphorylation Tomoki Kuwahara a,⁎ , Kai Funakawa a , Tadayuki Komori a , Maria Sakurai a , Gen Yoshii a , imgur blondelashes19Web4 mei 2024 · Lysosomotropic compounds affect prominent inflammatory messengers, such as IL1B, CCL4, CCL20, and IL6, as well as cathepsin L dependent viral entry (fusion) … imgur bethanyWeb1 okt. 2024 · 1. Antiviral effects of highly accumulating lysosomotropic drugs. Currently available antiviral drugs were mainly designed to target a specific viral or human protein crucial for infection with a specific type of virus [1].Considering the diversity and constant mutations of viruses, it will not come as a surprise if these antiviral drugs are shown to be … list of postal codes south africaWeb14 feb. 2013 · Blocked Autophagy Using Lysosomotropic Agents Sensitizes Resistant Prostate Tumor Cells to the Novel Akt Inhibitor AZD5363 Francois Lamoureux; Christian Thomas; Claire Crafter; Masafumi Kumano; Fan Zhang; Barry R. Davies; Martin E. Gleave; Amina Zoubeidi Author & Article Information Clin Cancer Res (2013) 19 (4): 833–844. list of postcode districts