WebMay 24, 2024 · When excess light chains enter the glomeruli with the blood, they mix with other proteins and clog the filters. These clogs inflame and injure the kidney tissue. This damage is called light chain cast nephropathy. Over time, this buildup of light chains can cause permanent damage and kidney failure. WebApr 1, 2024 · The serum free light-chain assay helps detect abnormal secretion of monoclonal light chains before they appear in the urine once the kidney tubules become saturated and unable to reabsorb them. Of note, the free light-chain ratio can be abnormal (< 0.26 or > 1.65) in chronic kidney disease.
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